美國莫菲特癌癥中心和研究所2023年招聘博士后職位（癌癥代謝）

Postdoctoral Fellow – Cancer Metabolism

H. Lee Moffitt Cancer Center

At Moffitt Cancer Center, we come face-to-face with cancer every day, but we also see courage. And it inspires us to be the safest and best place for cancer care – to bring greater hope to every patient we serve. It’s why we’ve been continually named One of the Top Places to Work in the Tampa Bay Area. As the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida, Moffitt employs some of the best and brightest minds from around the world. Moffitt is the leading cancer hospital in both Florida and the Southeast and has been nationally ranked by U.S. News & World Report since 1999. Because working at Moffitt is both a career and a mission: to contribute to the prevention and cure of cancer. Join a dedicated, diverse and inclusive team of over 7,000 to be a part of the Courageous future we envision.

Summary

Moffitt Cancer Center and Research Institute is proud to be Florida’s only National Cancer Institute-designated Comprehensive Cancer Center located in Tampa. We strive to be the leader in understanding the complexity of cancer through team science and applying those insights for human benefits. Every Team Member of Moffitt focuses on our lasting commitment to our mission: To contribute to the prevention and cure of cancer.

Postdoctoral Fellow – Cancer Metabolism

Research in the Ward Lab is centered on characterizing how systemic metabolism and nutritional status are transmitted to tumor cells via the microenvironment and how mitochondria integrate these metabolic signals during tumor progression and in response to therapy. Current projects in the lab are focused on how substrate availability influences iron-sulfur cluster biosynthesis (bioRxiv 2022.10.06.511221), a process critical to maintaining nearly all aspects of cellular function, and how the mitochondrial transhydrogenase (NNT) exerts its’ pleiotropic regulation of redox metabolism (PMID: 32196080). We are recruiting a postdoctoral fellow eager to explore these topics and other aspects of mitochondrial redox metabolism through the implementation of chemoproteomics, metabolomics, and super-resolution microscopy.

Position Highlights:

·Use of cutting-edge technologies (e.g. in vivo stable isotope tracing, cysteine-based chemoproteomics, and stimulated emission depletion [STED] super-resolution microscopy).

·Work as part of the Lung Cancer Center of Excellence, which bridges basic and clinical research.

·Work closely with Dr. Ward on the postdoctoral fellow’s career development (e.g., grant/manuscript writing, scientific presentations, and networking).

·Moffitt integrates excellent patient care with cutting-edge clinical and basic research. Having a cancer hospital on-site provides unique opportunities for translational research.

·Outstanding mentorship from expert faculty with wide-ranging funded research programs including T32 Training Grants.

The Ideal Candidate:

·Candidates with research experience in metabolism and/or mitochondrial biology are highly encouraged to apply.

·Practical experience with mass spectroscopy-based proteomics or metabolomics is highly desirable, but not required.

·Experience with mouse models of cancer is also highly desirable, but not required.

·Can think independently and has a strong desire to develop independent projects.

·Has excellent communication skills and the ability to work collaboratively as part of a team.

Responsibilities:

·Work independently and collaboratively for the mission of the lab.

·Design and execute experiments; analyze and interpret data

·Regularly present findings to the lab and at Moffitt-sponsored seminar series and symposia.

·Attend conferences to present findings to the broader scientific community.

·Mentor and train graduate and undergraduate students.

·Write manuscripts, postdoctoral fellowships, and assist with other funding applications.

Credentials and Qualifications:

·Ph.D. or M.D./Ph.D. in biology, biochemistry, biophysics, molecular biology, or a related field is required. Ph.D. candidates nearing the completion of their degree in relevant fields are encouraged to apply.

·At least one first-author publication or preprint is highly preferred.

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