職位描述：

　　NeuherbergbeiMünchen，巴伐利亞，德國

　　工作組：

　　功能表觀遺傳學研究所

　　研究領域：

　　科學/博士后職位

　　開始日期：

　　2019年4月1日

　　合同期限：

　　2021年3月31日

　　職位描述：

　　作為德國環境健康研究中心，HelmholtzZentrumMünchen致力于開發個性化醫療方法，以預防和治療糖尿病，過敏癥和肺病等主要常見疾病。為此，它研究了遺傳，環境因素和生活方式的相互作用。

　　慕尼黑亥姆霍茲中心的功能表觀遺傳學研究所（IFE）專注于了解表觀遺傳機制如何調節細胞的身份和功能。具體而言，我們想要揭示染色質修飾如何通過基因表達的變化來調節這些過程。我們的研究包括下一代測序（ChIPseq，RNAseq，CLIP等），單細胞方法，生物化學以及各種發育和細胞生物學系統。

　　對于我們的研究團隊，我們目前正在尋找一個

　　表觀遺傳學中的PostDoc（f / m / d）

　　2019/0047

　　職位描述

　　對于染色質生物化學，表觀遺傳學和表型遺傳學的間期項目，我們正在尋找具有強大研究背景，表觀遺傳學或染色質領域經驗以及經過驗證的出版記錄的PostDoc。成功的候選人將研究新的染色質修飾途徑，包括我們最近發現的DNA和RNA修飾，以解決表觀遺傳學中的一個核心問題：細胞環境控制基因表達程序和疾病狀態（如癌癥）的機制是什么？

　　該項目將涉及體外和體內方法的結合，包括不同的NGS（組學）技術及其分析，以及開發新的創新技術，以解決單細胞和低輸入材料的機制。它旨在使申請人在確定其方向方面發揮重要作用，同時受益于激烈的國際合作以及其他研究所成員的深刻的表觀遺傳學和染色質背景。

　　你的資格

　　這個職位的候選人應該：

　　生物學或相關領域的博士生染色質研究的強大研究背景，具有非常好的出版記錄至少有以下兩個領域的經驗是必不可少的：染色質生物化學ChIP seq和RNA seq技術（包括數據分析）單細胞方法流利的英語需要德語知識不需要

　　我們的意向

　　在HelmholtzZentrumMünchen，您可以與領先的研究人員共同研究糖尿病，慢性肺病和過敏等環境疾病的發展，預防和治療。為了進一步促進您的專業發展，我們提供廣泛和有針對性的研究培訓和職業計劃。我們通過靈活的工作時間模型，職業健康管理，兒童日托設施，兒童保育補貼，老年護理以及其他咨詢和支持服務，支持工作與私人生活之間的和解。

　　薪酬和福利符合公共服務集體協議（TV EntgO Bund）。該職位（最初）限于2年。

　　作為全面質量獎的持有者，我們促進機會均等。為了增加女性擔任管理職位的比例，我們很樂意收到相應的申請。合格的身體殘疾申請人將被優先考慮。

　　我們期待收到您的綜合在線申請，直到2019年3月31日。

　　英文原文：

　　Neuherberg bei München, Bavaria, Germany

　　Work group:

　　Institute of Functional Epigenetics

　　Area of research:

　　Scientific / postdoctoral posts

　　Starting date:

　　01.04.2019

　　Contract time limit:

　　31.03.2021

　　Job description:

　　As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.

　　The Institute of Functional Epigenetics (IFE) at the Helmholtz Center Munich focuses on understanding how epigenetic mechanims regulates cellular identity and function. Specifically we want to unravel how chromatin modifications regulate these processes through changes in gene expression. Our research includes next generation sequencing (ChIPseq, RNAseq, CLIP etc.), single cell approaches, biochemistry as well as various developmental and cell biology systems.

　　For our research team we are currently looking for a

　　PostDoc in Epigenetics (f/m/d)

　　2019/0047

　　Job Description

　　For a project on the interphase between chromatin biochemistry, epigenetics and epitranscriptomics we are looking for a PostDoc with a strong research background, experience in the epigenetics or chromatin field and a proven publication record. The successful candidate will study novel chromatin modifying pathways including DNA and RNA modifications, which we have recently identified, to address a central question in epigenetics: what are the mechanisms via which the cellular environment controls gene expression programs and disease states, such as cancer?

　　This project will involve a combination of in vitro and in vivo approaches, including different NGS (omics) techniques and their analysis as well the development of novel innovative technologies to address mechanism in single cells and low-input material. It is designed to allow the applicant to play a major role in determining its direction and at the same time benefit from intense international collaborations as well as the profound epigenetics and chromatin background of the other Institute members.

　　Your Qualification

　　Candidates for this position should have:

　　PhD in biology or a related field Strong research background in chromatin research with a very good publication recordExperience in at least two of the following fields is essential:Chromatin biochemistryChIP seq and RNA seq techniques (including data analysis)Single cell approachesFluent English is requiredknowledge of German is not required

　　Our Offer

　　At the Helmholtz Zentrum München, you can contribute together with leading researchers to the investigation of the development, prevention and treatment of environmental diseases such as diabetes, chronic lung diseases and allergies. In order to further promote your professional development, we offer extensive and targeted research training and career programmes. We support the reconciliation between work and private life with flexible working time models, occupational health management, day care facility for children, a childcare subsidy, Elder Care, as well as other counseling and support services.

　　Remuneration and benefits are in accordance with the collective agreement for the public service (TV EntgO Bund). The position is (initially) limited to 2 years.

　　As a holder of the Total E-Quality Award, we promote equality of opportunity. In order to increase the proportion of women in management positions, we would be pleased to receive corresponding applications. Qualified applicants with physical disabilities will be given preference.

　　We are looking forward to receiving your comprehensive online application until March 31st 2019.

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