美國國立衛生研究院運用X射線晶體學、核磁共振和電子顯微鏡研究中心體博士后職位招聘

　　Postdoc fellowship to study centrosomes using X-ray crystallography, NMR, and electron microscopy

　　Employer

　　National Institutes of Health

　　Location

　　Bethesda, Maryland, and Washington D.C. area

　　Salary

　　Starts at $55,700 for fellows with 0 yr postdoc training (+ annual raise) and full health insurance

　　Posted

　　February 12 2020

　　Ref

　　Postdoctoral fellowship

　　Discipline

　　Life Sciences, Biochemistry, Structural Biology

　　Position Type

　　Full Time

　　Organization Type

　　Academia

　　Job Type

　　Postdoc Fellowship

　　Investigating the architecture and function of nanoscale centrosomal self-assemblies using X-ray crystallography, NMR, biochemistry, and electron microscopy

　　Position Description:  The architecture of a cell is established through varying degrees of hierarchical organizations from single molecules to macromolecular assemblies.  Investigating how these molecules interact with one another to form a higher-order structural entity with a new biological function is a key step to unlocking the mystery of life.  We are mainly interested in understanding the molecular bases of how the physicochemical properties of pericentriolar scaffold proteins drive the formation of micron-scale self-assemblies with distinct cellular functions.  Recently, we found that human polo-like kinase 4, a key regulator of centriole duplication, forms a high M.W. complex with centrosomal scaffold proteins, which cooperatively self-assemble into a higher-order architecture around a centriole in a concentration-dependent manner. Notably, a failure in these events can result in abnormal centrosome numbers, improper spindle formation, and chromosome missegregation that ultimately lead to the development of various human diseases, including cancer, ciliopathy, and microcephaly.  Thus, we aim to elucidate the molecular mechanism underlying the assembly of pericentriolar architectures to ultimately understand the etiology of centrosome-associated human diseases.

　　Fellows who have an expertise in structural biology (X-ray or NMR) and/or electron microscopy with a keen interest in investigating the structure and function of nanoscale centrosomal self-assemblies are encouraged to apply.

　　Applicants should have a Ph.D. (or expected) or M.D. equivalent at the time of joining the lab. For more information, please click the link below.

　　https://ccr.cancer.gov/Laboratory-of-Metabolism/kyung-s-lee

　　To apply, please send CV and three names of references to Dr. Kyung Lee (kyunglee@mail.nih.gov).

　　Salary starts at $55,700 for fellows with 0 yr postdoc training (+ annual raise) and full health insurance

　　Employer Name: National Cancer Institute, NIH.

　　Position Location: 9000 Rockville Pike, Bethesda, MD 20892, U. S. A.

　　Selected publications:

　　1.      Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis. Park JE, et al. Nat Commun. 10(1):4959, 2019.

　　2.      Molecular architecture of a cylindrical self-assembly at human centrosomes. Kim TS, et al. Nat Commun. 10(1): 1151, 2019.

　　3.      Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis. Park SY, et al. Nat. Struct. Mol. Biol. 21(8): 696-703, 2014

　　The NIH is dedicated to building a diverse community in its training programs.

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