Join a Team that Lives to Improve Lives People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what’s possible. And a focus on doing the day-to-day work that makes great science happen.

The following opportunity exists in our South San Francisco, CA headquarters:

Postdoctoral Research Fellow – Early Biochemistry, Hannoush Lab

Description

We have an exciting opportunity for a highly motivated postdoctoral fellow to join the Department of Early Discovery Biochemistry at Genentech. The postdoctoral candidate will investigate protein – protein interactions and develop peptide probes for modulating targets of therapeutic interest by utilizing biochemical, biophysical and structural biology approaches. The group utilizes a multidisciplinary molecular approach for peptide discovery and target validation, encompassing diversity methods such as phage display. Projects will focus on molecular understanding of new targets and protein complexes that are important in cancer and stem cell biology and dissecting their biochemical mechanisms of regulation. The individual will work independently in a team-oriented environment and collaborate with experts in oncology and immunology to apply the pharmacological strategies to study cellular signaling pathways. Proficiency in X-ray crystallography and/or cryo-EM methods is strongly preferred.

For information about the Genentech Postdoctoral Program, visit:

https://www.gene.com/careers/university-and-early-career/postdocs

For information about the Postdoctoral Program at Genentech, visit:

https://www.gene.com/scientists/our-scientists/rami-hannoush

Relevant References:

A Nile, F de Sousa E Melo, S Mukund, R Piskol, S Hansen, L Zhou, Y Zhang, Y Fu, E Gogol, L Kömüves, Z Modrusan, S Angers, Y Franke, C Koth, W Fairbrother, W Wang, F de Sauvage, RN Hannoush. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nature Chemical Biology 2018, 14, 582-590.

A Nile, S Mukund, K Stanger W Wang and RN Hannoush. Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt binding. PNAS 2017, 114, 4147-4152.

X Gao, K Stanger, H Kaluarachchi H, T Maurer, P Ciepla, C Chalouni, Y Franke, RN Hannoush. Cellular uptake of a cystine-knot peptide and modulation of its intracellular trafficking. Sci Rep. 2016, 6:35179.

X. Gao, RN Hannoush, Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine. Nature Chemical Biology 2014, 10, 61-68.

Who You Are

Requirements:

Candidates must have a Ph.D. in biochemistry, biophysics, structural biology or related discipline and a proven record of productivity in their graduate career as demonstrated by first-author publications.

Additional Recommended Qualifications:

• Strong experience in molecular biology • Expertise in engineering, expressing and purifying challenging proteins • Proficient in structural biology and / or cryo-EM • Experience with directed evolution (yeast, phage, mRNA display, etc.) is preferred • Experience with tissue culture, cell-based assays is a plus. • Strong analytical, collaborative, communication and organizational skills

A Job with Benefits Beyond the Benefits A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the “Apply online” button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.

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