Post-Doctoral Research Fellow, Immunotherapy

Fred Hutchinson Cancer Research Center

Seattle, WA, United States

Expires on January 18, 2021

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

The post-doctoral research fellow will work on independent and collaborative projects in Dr. Chapuis’ laboratory developing adoptive T cell immunotherapy within the Program in Immunology and Clinical Research Division at Fred Hutchinson Cancer Research Center. This highly translational research will include monitoring patients through-out the course of immunotherapy treatment, and use the data generated for immunological informed decisions that will affect the course of treat for patients.

Additionally, the successful applicant will employ strategies for improving current immunotherapy treatments, including and not limited to; cloning T cell receptors (TCRs) and genetic modification of human T cells with TCRs specific for antigens expressed by malignancies. In vitro studies using human T cells and in vivo murine models will be used to develop and test novel T cell therapies. The research fellow will perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy.

The Program in Immunology is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach. The post-doctoral research fellow may also participate in the laboratory evaluation of ongoing clinical trials involving engineering of peripheral blood stem cell grafts for improved allogeneic hematopoietic stem cell transplantation outcomes, and in the development of future immunotherapy strategies. This is a full-time position with a salary based on the NIH scale and excellent benefits.

Responsibilities

◦Study the function and persistence of T cells in clinical trial patients

◦Organize and track patient samples, assays, and data

◦Cell Culture, cell sorting, flow cytometry, intracellular staining, and transfections

◦Molecular bench work with PCR, cloning, and vector design

◦ NGS including, Single cell RNA sequencing, WEX, WGS

◦Biostatistics and some basic programing

◦Validation through functional and killing assays

◦Write and submit grants and first author papers to peer reviewed journals

◦Stay current with relevant publications and apply knowledge to research

◦Compile data and synthesize innovative problem-solving methods

◦Collaborate and present data with a wide range of stakeholders and partners

◦Train others on protocols

◦Mentor and lead undergraduate and graduate students

◦Assist with lab maintenance and function

Qualifications

Minimum Qualifications

◦MD and/or a PhD in a biological science with a diverse knowledge of immunology

◦Proficient in immunology technique and knowhow

◦Strong scientific writing skills, ability to write and apply for funding opportunities and abstracts

◦Able to digest complex material and synthesize innovative ideas

◦Compile and clearly present data to an eclectic audience, both orally and written

◦Well versed in flow cytometry

Preferred Qualifications

◦Experience with molecular techniques lentiviral modification of T cells

◦Experience in analysis of TCR signaling pathways and T cell function

◦Familiarity with biostatistics, R and Python languages

◦Ability to derive and maintain T cell tissue cultures

◦Have a good understanding of SRAs and/or phase I/II clinical trials

To be successful, the post-doctoral research fellow must be: highly motivated and driven, able to work independently and with others, be open to receive and provide feedback for scientific discussion and general lab work, possess an acute attention to detail and organizational skills, think critically and problem solve and be excellent at note taking and reproducibility.

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Our Commitment to Diversity

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer.  We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected.  We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class.  We are an Affirmative Action employer.  We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our HR Operations at HRops@fredhutch.org or by calling 206-667-4700.

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