彭敏博士在免疫代謝和營養信號轉導方面進行了深入的研究，發現多種調控營養信號轉導的關鍵分子以及代謝通路調控免疫細胞分化的分子機制，相關研究成果發表在Cell、Nature及Science等國際學術期刊，并獲得“求是”杰出青年學者獎。目前， 彭敏博士致力于使用高通量功能基因組學技術系統性地研究T淋巴細胞增殖分化的調控機理以及細胞代謝調節免疫應答等的分子機制，并利用這些分子機理為免疫相關疾病的診斷和治療提供新策略和新靶點。

實驗室研究方向：

T cells play essential roles in immune response. We are studying T cells with two directions:

1. Functional genomics in primary T cells

We are applying genome-wide CRISPR/Cas9 screen in primary T cell in vivo to answer fundamental questions in T cell biology, including development, activation, proliferation and differentiation, as well as T cell fitness (e.g. exhaustion) in tumor microenvironment.  Identified novel genes and regulatory circuits have been used to design novel therapies for diseases.

2. Mechanisms of metabolic regulation of T cells

Metabolic reprogramming is a hallmark of T cell activation, but how metabolic pathways regulate T cell function remains poorly understood. We are using mouse models with gain- and loss-of-function of key metabolic enzymes to decipher metabolic regulation T cell, and try to target metabolism to treat immune-related diseases.

參考文獻：

1. Hanfei Zhao, Ying Liu, Lixia Wang, Gang Jin, Xiaocui Zhao, Jing Xu, Guangyue Zhang, Yuying Ma, Na Yin, Min Peng. Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity. Cell Reports. 2021 Dec 7;37(10):110083.

2. Ke Xu*, Na Yin*, Min Peng, Efstathios G Stamatiades, Sagar Chhangawala, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Kristelle J Capistrano, Chun Chou, Christina S Leslie, Ming O Li. Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses. Immunity. 2021. 54(5):976-87.  

3. Ke Xu, Na Yin, Min Peng, Efstathios G Stamatiades, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Zhaoquan Wang, Kristelle J Capistrano, Chun Chou, Andrew G Levine, Alexander Y Rudensky, Ming O Li. Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity. Science. 2021.371(6527):405-10.

4. Min Peng*, Na Yin*, Sagar Chhangawala, Ke Xu, Christina S. Leslie, Ming O. Li. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science. 2016 Oct 28; 354(6311): 481-484.

Preview in Science, 2016 Oct 28; 354(6311): 419-420. “Warburg meets epigenetics”.

Preview in Dev Cell, 2016 November 7;39: 286-287. “Metabolic Control of Cellular Differentiation”.

Preview in Cell Metab, 2016 November 8; 24: 651-652. “Metabolic Signaling Drives IFN-g”.

5. Min Peng, Na Yin, Ming O. Li. SZT2 dictates GATOR control of mTORC1 signaling. Nature. 2017 Mar 16;543(7645):433-437.

6. Min Peng, Na Yin, Ming O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell. 2014 Sep 25; 159(1): 122-33.

博士后招聘

CAR-T腫瘤治療方向2名：

應聘條件：具有免疫學、分子和細胞生物學相關專業博士學位，獲得博士學位2年以內；近期以第一作者身份在國際知名學術期刊發表研究論文，符合清華大學博士后入站標準；熱愛科研工作，責任心強，具備團隊合作精神；具備較好的英語溝通、閱讀和寫作能力。

崗位待遇： 崗位待遇按照清華大學相關規定執行。課題組將根據工作情況提供一定生活補助和績效獎勵。另外，根據本單位相關規定，博士后以第一作者、清華大學為第一單位發表高水平學術期刊可獲得有非常有競爭力的績效獎勵（http://postdoctor.tsinghua.edu.cn/）。

申請方式：將簡歷（包括學歷和論文發表情況）、研究自述（研究興趣、成果以及未來職業規劃）、及2-3名推薦人的聯系方式發至：pengmin@tsinghua.edu.cn；主題標明“姓名+應聘博士后 “。

信息來源于網絡，如有變更請以原發布者為準。

來源鏈接：

http://www.cls.edu.cn/Careers/Postdoctoral5565.shtml

為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標題格式：應聘職位名稱+姓名+學歷+專業+中國博士人才網）