一、中心簡介

首都醫學科學創新中心（簡稱創新中心）是北京市新成立的具有獨立法人資格的新型研發機構。創新中心以推動醫學科學發展、改善人類健康為目標，開展生物醫學研究，致力于提升醫學科學創新與成果轉化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學家，與首都醫學教育和科學研究優質資源緊密合作，打造多學科交叉融合的科研平臺，綜合自由探索、醫學目標導向、有組織科研等途徑，實踐新型科研模式和體制機制，逐步推進醫教研產的深度融合，培養適應醫學科學創新發展的優秀人才。

二、實驗室介紹

首都醫學科學創新中心姜漢杰課題組現面向國內外招聘博士后與科研助理，課題組專注于利用化學生物學方法解碼蛋白質翻譯后修飾在癌癥和其他疾病中的功能，并探索潛在的疾病治療策略。課題組堅持科學點亮生活，鼓勵開放交流，支持成員學習成長，希望認真研究同時認真生活，立志為癌癥等疾病貢獻新的解題思路。如果你想一邊和志同道合的人們研究前沿科學，一邊享受實驗室的快樂氛圍，趕緊看過來！

姜漢杰研究員畢業于北京大學，本碩階段的導師為蒲小平教授，于2022年在約翰霍普金斯大學獲得藥理學與分子科學的博士學位，師從PhilipCole教授，期間主要研究泛素連接酶的功能調節和底物識別機制，之后繼續在哈佛醫學院/布萊根婦女醫院完成了博士后訓練，應用化學生物學手段探究泛素連接酶的催化機制。姜漢杰研究員于2025年2月加入首都醫學科學創新中心。

三、主要研究方向

1.開發和應用蛋白質半合成、分子探針等化學方法，研究酶及細胞信號通路中的蛋白質磷酸化、泛素化等翻譯后修飾。

2.探索蛋白質泛素及類泛素修飾的調控機制以及其在疾病發生中的病理機制，鑒別新的治療靶點。

3.開發靶向泛素化的合成生物學工具，為基礎研究和疾病治療提供新方法。

四、主要成果

1.發現HECT家族E3連接酶末端羧基參與泛素轉移的催化機制。

2.揭示HECT家族E3連接酶中的自抑制和激活機制。

3.開發特異性的蛋白質N端標記方法。

代表性文章

Jiang et al., 2024, Nature Chemistry, PMID:39030419

Jiang et al., 2022, JBC, PMID:35331737

Jiang et al., 2019, JBC, PMID:31578285

Dempsey, Jiang et al., 2018, JACS, PMID:30016585

Chen, Jiang et al., 2017, Molecular Cell, PMID:28475870

五、崗位信息

01博士后

1）任職要求

1.近三年已獲得或即將獲得生命科學、化學、藥學或相關專業的博士學位，具有生物化學與分子生物學、藥理學、蛋白設計、藥物開發等研究背景者優先考慮；

2.有責任心和團隊精神，誠實誠信，心態陽光，熱愛創新與挑戰;

3.能獨立地開展科研工作；

4.具備較好的英文溝通、寫作能力。

02科研助理

1）任職要求

1.本科及以上學歷，生命科學、化學、藥學、醫學等相關專業；

2.可獨立或協助開展實驗室研究工作，管理和維護實驗室的日常事務；

3.有責任心和團隊精神，誠實誠信，心態陽光，熱愛創新與挑戰；

4.具備基本的英文溝通、寫作能力。

六、福利待遇

1.根據應聘者的工作經驗和能力，提供具有市場競爭力的薪酬（詳情面談）；

2.享受五險一金、帶薪年假、體檢和補充醫療保險等；

3.支持個人職業發展，提供必要的工作相關專業培訓；協助申報各類科研基金和人才項目。

七、申請方法

請將簡歷、個人陳述（1頁）、2名推薦人的基本信息和聯系方式、工作總結與研究興趣（1-2頁，僅限博士后）以及其他申請人認為必要的材料，合并為PDF文件發送至hjiang@cimrbj.ac.cn ，并在郵件主題中注明：“應聘博士后/科研助理+本人姓名+所在學校/單位”，初審通過的申請者將會盡快安排面試。

聯系人：姜老師

聯系地址：北京市豐臺區右安門外西頭條10號-首都醫學科學創新中心

本招聘長期有效，至招聘到合適人選為止。

ABOUT CIMR

The Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research. The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment. For more information, please visit our website: www.cimrbj.ac.cn

Laboratory Introduction

The Jiang lab at CIMR now has open positions for postdoctoral fellows and research assistants. The lab is dedicated to using chemical biology approaches to decode the functions of protein post-translational modifications (PTMs) in cancer and other diseases, with a focus on advancing innovative therapeutic strategies. We firmly believe science makes life better, encourage open communication, and fully support our members in learning and personal development. Our goal is to balance dedicated research with a fulfilling life. We are committed to contributing to new solutions for cancer and other diseases. If you’re after cutting-edge science mixed with a fun and supportive lab environment, read on!

Dr. Jiang graduated from Peking University with Bachelor’s and Master’s degrees under the supervision of Dr. Xiaoping Pu. He received his Ph.D. degree in Pharmacology and Molecular Sciences from the Johns Hopkins University with Dr. Philip Cole in 2022, where he studied the regulation mechanisms and substrate selectivity of HECT family E3 ligases. He then completed his postdoc training in the Cole lab at Harvard Medical School and Brigham and Women’s Hospital, where he focused on illustrating the catalytic mechanisms of HECT E3 ligases using chemical biology approaches. Dr. Jiang joined CIMR faculty in February, 2025.

Major Research Projects

a. Developing and applying chemical methods, such as protein semisynthesis and molecular probes, to investigate protein ubiquitination, phosphorylation, and other PTMs in key enzyme and cellular signaling pathways.

b. Exploring the regulatory mechanisms of ubiquitin and ubiquitin-like modifications and their pathological roles in disease progression to identify novel therapeutic targets.

c. Designing and optimizing synthetic biology tools for targeted ubiquitination to provide innovative methods for basic research and translational medicine.

Major Contributions

a. Discovered the catalytic role of terminal carboxylate involvement in ubiquitin transfer by HECT E3 ligases.

b. Uncovered the autoinhibition and activation mechanisms in HECT E3 ligases.

c. Developed a specific protein N-terminal labeling method.

Representative Publications

Jiang et al., 2024, Nature Chemistry, PMID:39030419

Jiang et al., 2022, JBC, PMID:35331737

Jiang et al., 2019, JBC, PMID:31578285

Dempsey, Jiang et al., 2018, JACS, PMID:30016585

Chen, Jiang et al., 2017, Molecular Cell, PMID:28475870

Open Positions

Postdoctoral Researcher

Qualifications

a. Have obtained or be about to obtain (within the past three years) a Ph.D. in life science, chemistry, pharmacology or a related field. Candidates with a strong background in fields, such as biochemistry and molecular biology, pharmacology, protein design or targeted-based drug development are preferred.

b. Highly responsible, honest with a positive mindset, and unafraid of trying new approaches.

c. Capable of conducting research independently.

d. Competent in English communication and writing skills.

Research Assistant

Qualifications

a. Bachelor’s degree or above in life sciences, chemistry, medicine, or a related field.

b. Capable of conducting research collaboratively or independently; Able to assist with daily lab operations.

c. Highly responsible, honest with a positive mindset, and unafraid of trying new approaches.

d. Basic English communication and writing skills are required.

Welfare Treatment

a. Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).

b. Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c. Support career development, provide relevant professional guidance, and support grant or talent program applications.

How to apply

Please compile your CV, one-page personal statement, basic information and contact details of two referees and a 1-2 page research summary and interests (for postdoc position only),  as well as other materials demonstrating research capabilities into a single PDF file. Send it to hjiang@cimrbj.ac.cn, and indicate “Postdoc/Research Assistant + Your Name + University/Employer” in the email subject. Review of applications will begin on a rolling basis, and qualified applicants will be invited for an interview.

Contact person: Dr. Jiang

This recruitment is valid for the long term until a suitable candidate is recruited.

信息來源于網絡，如有變更請以原發布者為準。

來源鏈接：

https://mp.weixin.qq.com/s/zlGAfha54bgvb5Oc2wzACQ

為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標題格式：應聘職位名稱+姓名+學歷+專業+中國博士人才網）