法國斯特拉斯堡大學2023年招聘博士后職位（生物/藥用無機化學）

斯特拉斯堡大學（法: Université de Strasbourg；德：Universität Straßburg；英：University of Strasbourg），簡稱UDS或Unistra，位于法國阿爾薩斯大區下萊茵省斯特拉斯堡市，是一所綜合性大學，法國卓越大學計劃高校。

學校成立于1538年，1971年因法國五月風暴影響拆分為三個獨立的大學，于2009年1月1日重新整合為現在的斯特拉斯堡大學。斯特拉斯堡大學在很多領域都享有盛名，擁有18名諾貝爾獎得主，1名菲爾茲數學獎得主。

Postdoc Position In Bio/Medicinal Inorganic Chemistry: Luminescent Sensor To Detect The Labile Cu(Ii)-Pool, A Diagnostic Parameter For Wilson’S And Alzheimer’S Disease

Universities and Institutes of France

France

October 31, 2023

Contact:N/A

Offerd Salary:Salary: Net ca.

Location:N/A

Working address:N/A

Contract Type:Other

Working Time:Full time

Working type:N/A

Ref info:N/A

17 Aug 2023

Job Information

Organisation/Company

University of Strasbourg

Research Field

Chemistry » Inorganic chemistry

Chemistry » Biochemistry

Researcher Profile

Recognised Researcher (R2)

Country

France

Application Deadline

31 Oct 2023 - 12:00 (Europe/Amsterdam)

Type of Contract

Temporary

Job Status

Full-time

Offer Starting Date

1 Feb 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

PostDoc position for 2 years on the project “ Luminescence detection of exchangeable Copper(II) traces in biological fluids” financed by the French National Research Agency (ANR) in the group of Biometals and Biological Chemistry (BCB) headed by Prof. Dr. Peter Faller, Institut de Chimie, UMR 7177 University of Strasbourg / CNRS; Group webpage: https: // bcb.chimie.unistra.fr/

Interdisciplinary project with several collaborators from different disciplines, Group of G. Ulrich (ICPEES, Strasbourg): synthesis and characterization of organic fluorophores; O. Seneque (CEA, Grenoble) synthesis and characterization of Lanthanide-Antenna units; N. Djebrani- Oussedik and A Poujois (Hôpital Lariboisière Paris, and Reference center for Wilson's disease): measure of clinical relevant blood plasma samples.

Project:

Background: Copper is an essential trace element for most living beings. Most copper is tightly bound to proteins. Only very little copper is labile bound to biomolecules and can rather rapidly be exchanged or transferred to other molecules. This exchangeable pool mainly exists extracellularly, where Cu is predominantly present in its oxidized form Cu(II). The project's aim is to elaborate a ratiometric or turn-ON luminescent Cu(II)-sensor, that is able to measure specifically labile/exchangeable Cu(II)-concentrations in biological systems, from simpler cell culture medium to the challenging blood plasma. Such a Cu(II)-sensor would be very useful as a tool to understand the Cu metabolism and might have applications for diagnosis of diseases with increased exchangeable Cu pool concentrations such as Wilson's or Alzheimer's disease.

PostDoc project: The project consist of the assembly of the different units of the Cu(II)-sensors on a peptide backbone. The sensor has a peptidic Cu(II)-binding unit, one or two luminophores (either fluorophore or Ln- Antenna) which are provided by the collaborators. The main tasks are to synthesize the peptide backbone with integrated Cu(II)-binding site and conjugate the luminophores. Next step will then be to test the sensor, in different biological fluids from buffer solution up to blood serum, and last on clinical relevant samples.

Recent references related to the topic from the group:

Falcone et al. Chem Commun. 2020, 56:4797, Okafor et al. Chem Sci. 2022, 13:11829 , Falcone et al. J Inorg Biochem. 2021, 221:111478, Falcone et al. Dalton Trans. 2019, 48: 14233.

Methods to be used: mainly bioinorganic chemistry with spectroscopy (Luminescence, fluorescence, NMR, EPR, CD, etc), but also peptide synthesis and inorganic complexation, biochemical techniques (chromatography,…).

Profile searched: Candidate with a recent PhD in (bio)chemistry or related discipline. Experience in biochemistry or biological inorganic chemistry would be welcome, but are not a prerequisite.

Starting date: First months of 2024 (to be determined)

Salary: Net ca. 2100 Euros/month

Applications: CV with coordinates of scientist able to give a recommendation and letter of motivation, should be send from now and before end of October 2023 to pfaller@unistra.fr

Requirements

Research Field

Chemistry » Biochemistry

Education Level

Master Degree or equivalent

Additional Information

Website for additional job details

https: // bcb.chimie.unistra.fr/

Work Location(s)

Number of offers available

1

Company/Institute

Institut de Chimie , University of Strasbourg

Country

France

City

Strasbourg

Street

4 rue B. Pascal

Geofield

Where to apply

E-mail

pfaller@unistra.fr

Contact

City

Strasbourg

Website

https: // bcb.chimie.unistra.fr/

Street

Institut le Bel, 4 Rue Blaise Pascal

Postal Code

67081

STATUS: EXPIRED

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